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姓名：李星 |
职称：教授 |
电子信箱：xingli_xian@vip.163.com |
研究方向： 1.少突胶质细胞分化机制研究；2.外泌体介导的脱髓鞘疾病治疗研究；3.针对神经免疫疾病的天然药物筛选及分子机制研究。 |
办公地点：格物楼3101-3 |
研究生招生单位：西北濒危药材资源开发国家工程实验室 |
一、个人简介
李星，教授，博导。2012年毕业于陕西师范大学，获理学博士学位。2013年1月至2016年10月在美国托马斯杰弗逊大学神经病理学研究所从事博士后研究。现阶段主要从事胶质细胞发育及相关疾病分子机制、靶向中枢神经系统药物精准递送研究工作。近年来主持国家自然科学基金项目4项、陕西省重点产业链项目、陕西省自然科学基金、陕西省留学人员科技活动择优资助等项目。以第一或通讯作者在Bioactive Materials、Molecular Therapy、Journal of Neuroinflammation、Progress in Neurobiology等期刊发表研究论文40余篇。目前担任《Military Medical Research》《Extracellular Vesicles and Circulating Nucleic Acids》等期刊学术编辑。
二、承担的科研项目
1. 国家自然科学基金面上项目，髓鞘碎片通过LSS-LDLR级联效应调控吞噬型OPCs细胞属性转换的作用及机制研究，2025/01-2028/12，82471421，主持人；
2. 国家自然科学基金面上项目，髓鞘碎片吞噬在少突胶质前体细胞命运决定中的调节作用和机制研究，2023/01-2026/12，82271199，主持人；
3. 陕西省教育厅基础科学研究项目，脱髓鞘病灶部位OPC功能异质性及其代谢内稳态调控研究，2024/01-2025/12, 23JHQ057，主持人；
4. 国家自然科学基金面上项目，炎症微环境下细胞外囊泡介导的小胶质细胞调控少突胶质前体细胞分化的作用机制研究，2020/01-2023/12，31970771，主持人；
5. 陕西省重点产业创新链（群）-社会发展领域，基于靶向性外泌体递送芬戈莫德治疗脱髓鞘疾病的应用研究，2021/01-2023/12，2021ZDLSF03-09，主持人；
6. 国家自然科学基金青年项目，miR-23b在EAE模型中促进髓鞘再生的作用机制研究，2016/01-2018/12，81501062，主持人；
7. 陕西省自然科学基金青年项目，甘草酸调控Mmrn2促进髓鞘再生的分子机制研究，2018/06-2019/12，2018JQ8033，主持人；
8. 陕西省留学人员科技活动择优资助项目，Latexin调节少突胶质细胞分化的分子机制研究，2018/01-2019/12，2017043，主持人；
9. 中央高校优秀青年创新团队项目，髓鞘碎片在神经髓鞘损伤疾病中的作用机制研究，2022/01-2024/12，GK202201013，主持人；
10. 中央高校专项基金，基于细胞外囊泡的靶向修饰药物载体用于新型冠状病毒肺炎的治疗研究，2020/01-2021/12，GK202007022，主持人；
11. 中央高校基金，小胶质细胞源性细胞外囊泡miRNA阻碍少突胶质前体细胞分化的作用及机制研究，2019/01-2020/12，GK201903062，主持人；
12. 中央高校基金，小分子P7C3在实验性自身免疫性脑脊髓炎中的神经保护作用机制研究，2017/01-2018/12，GK201703079，主持人。
三、近五年代表性论文
1. Ji XY*, Guo YX*, Wang LB*, Wu WC*, Wang JQ, He J, Gao R, Rasouli R, Gao MY, Wang ZH, Xiao D, Zhang WF, Ciric B#, Zhang Y#,Li X#. Microglia-derived Exosomes Modulate Myelin Regeneration via miR-615-5p/MYRF Axis. Journal of Neuroinflammation. 2024,21(1)：29. (SCI I区，Top journal, IF=9.3)；
2. Bao MY, Feng CY*, Li XQ*, He Y, Han B, Yang YY, Zhang Y#,Li X#. Targeting of KOR by famotidine promotes OPC maturation differentiation and CNS remyelination via STAT3 signaling pathway. International Journal of Biological Macromolecules. 2024; 269(Pt 2):131964. (SCI I区，Top Journal，IF=8.2)
3. He J, Wang Y, Zhao ZH, He JY, Gao MY, Wang JQ, Wang LB, Zhang Y,Li X#. Exosome-specific loading Sox10 for the treatment of Cuprizone-induced demyelinating model. Biomedicine and Pharmacotherapy. 2024; 171:116128.（SCI II区，Top, IF=7.5）；
4. Gao R, Song SJ, Tian MY, Wang LB, Zhang Y,Li X#. Myelin debris phagocytosis in demyelinating disease. Glia. 2024; DOI: 10.1002/glia.24602. (SCI II区，IF=5.4).
5. Wang JQ*, Li Q*, He JY, Zhou F, Huang ZH, Wang LB, Zhang Y,Li X#. Autophagy in demyelinating diseases: phagocytosis and autophagy of oligodendrocyte precursor cells. Molecular Neurobiology. 2024; DOI: 10.1007/s12035-024-03996-x. (SCI II区，IF=5.1);
6. Zhang Y*, Song SJ*, He J, Zhao ZH, Zhang K, Zhang Y,Li X#. Targeted Drug Delivery to ACE2+ Cells Using Engineered Extracellular Vesicles: A Potential Therapeutic Approach for COVID-19. Current Pharmaceutical Biotechnology. 2024; (IF=2.8);
7. Yang Y*, Han Bing*, Zhang MQ, Chai NN, Yu FL, Qi WH, Tian MY, Sun DZ, Huang Y, Song QX, Li Y, Zhu MC, Zhang Y#,Li X#. Therapeutic effects and mechanisms of isoxanthohumol on DSS‑induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders. Inflammopharmacology. 2024;https://doi.org/10.1007/s10787-024-01472-5. (SCI II区，IF=5.8);
8. Han B*, Shi L*, Bao MY*, Yu FL, Zhang Y, Lu XY, Wang Y, Li DX, Lin JC, Jia W#,Li X# and Zhang Y#. Dietary ellagic acid therapy for CNS autoimmunity: Targeting on Alloprevotella rava and propionate metabolism. Microbiome. 2024; doi: 10.1186/s40168-024-01819-8.（SCI I区，Top Journal，IF=15.5）
9. Xiao Y*, Tian J*, Wu WC*, Gao YH, Guo YX, Song SJ, Gao R, Wang LB, Wu XY, Zhang Y#,Li X#.Targeting central nervous system extracellular vesicles enhanced triiodothyronine remyelination effect on experimental autoimmune encephalomyelitis. Bioactive Materials. 2022; 9:373-384.(SCI I区, Top journal,IF=14.593);
10. Xiao Y*, Wang SK*, Zhang Y*, Rostami A, Kenkare A,Casella G, Yuan ZQ#,Li X#.Role of extracellular vesicles in neurodegenerative diseases. Progress in Neurobiology. 2021; 201:102022. (SCI I区, IF=11.685);
11. Zhang Y, Han J, Liang X, Zhao L, Zhang F, Rasouli J, Wang Z, Zhang G#,Li X#. MiR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by targeting CCL7. Molecular Therapy. 2018; 26(2):582-592. (SCI I区, Top journal, IF =8.988,);
12. Gao MY, Wang JQ, He J, Gao R, Zhang Y,Li X#. Single‑Cell RNA‑Sequencing in Astrocyte Development, Heterogeneity, and Disease. Cellular and Molecular Neurobiology. 2023; (SCI III区,IF=4.0)
13. Gao YH*,Li X#. Cholesterol metabolism: Towards a therapeutic approach for multiple sclerosis.Neurochemistry International. 2023; 164:105501.(SCI III区,IF=4.297).
14. Wang JQ, Gao MY, Gao R, Zhao KH, Zhang Y,Li X#. Oligodendrocyte lineage cells: Advances in development, disease, and heterogeneity. Journal of Neurochemistry. 2023; 164(4):468-480. (SCIII区,Top journal,IF=5.546);
15. WuWC*, Tian J*, Xiao D*, Guo YX, Xiao Y, Wu XY, Casella G, Rasouli J, Yan YP, RostamiA, WangLB, ZhangY#,LiX#.Engineered extracellular vesicles encapsulated Bryostatin-1 as therapy for neuroinflammation. Nanoscale. 2022; 14(6):2393-2410. (SCIII区,Top journal,IF=7.790);
16. Han B*,Li X*, Ai RS*, Deng SY, Ye ZQ, Deng X, Ma W, Xiao S, Wang JZ, Wang LM, Xie C, Zhang Y, Xu Y, Zhang Y#.Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation. eLife. 2022; 11.e72247. (SCII区, Top journal, IF=8.713, *co-first author);
17. Wu XY*, Liao BY*,Xiao D*, Wu WC, Xiao Y, Alexander T, Song SJ, Zhao ZH, Zhang Y, Wang ZH, Wang LB#,Li X#.Encapsulation of bryostatin-1 by targeted exosomes enhances remyelination and neuroprotection effects in the cuprizone-induced demyelinating animal model of multiple sclerosis. Biomaterials Science.2022;10(3):714-727. (SCI II区, IF=6.843);
18. Gao YH*, Zhang Y*, Guo YX, Wang JQ,Li X#. Treatment with anacardic acid modulates dendritic cell activation and alleviates the disease development of autoimmune neuroinflammation in mice.Biochemical and Biophysical Research Communications. 2022; 613:34-40. (SCI III区, IF=3.575);
19. Xiao Y*, Zhang Y*, Gao YH, Zhao ZH, He J, Gao R, Guo YX, Wang LB,Li X#. A targeted extracellular vesicles loaded with montelukast in the treatment of demyelinating diseases.Biochemical and Biophysical Research Communications. 2022; 594:31-37. (SCI III区, IF=3.575);
20. Li X*, Zhang Y*, Zhang WF, Xiao D, Ciric B, Rostami A, Zhang G.P7C3 attenuates CNS autoimmunity by inhibiting Th17 cell differentiation.Cellular & Molecular Immunology. 2021; 18(6):1565-1567.(SCI I区, Top journal, IF =11.530);
21. Shen PX*,Li X*, Deng SY*, Zhao L*, Zhang YY, Deng X, Han B, Yu J, Li Y, Wang ZZ, Zhang Y#. Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor. EBioMedicine. 2021; 64:103227.(SCII区, Top journal, IF=8.140, *co-first author);
22. Lu XY*, Han B*, Deng X, Deng SY, Zhang YY, Shen PX, Hui T, Chen RH,Li X#, Zhang Y#. Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota. Gut microbes. 2020; 12(1):1857515. (SCI I区, IF=10.245,#co-correspondence author);
23. Zhang Y*,Li X*, Ciric B, Curtis M, Chen W, Rostami A#, Zhang G#.A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.Proceedings of the National Academy of Sciences. 2020; 117(16):9082-9093. (SCI I区, Top journal, IF =11.205, *co-first author)；
24. Shen PX*,Li X*, Deng SY*, Zhao L*, Zhang YY, Deng X, Han B, Yu J, Li Y, Wang ZZ, Zhang Y#. Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor. EBioMedicine. 2021; 64:103227. (SCII区, Top journal, IF=8.143, *co-first author);
25. Han B*, Zhang YY*, Ye ZQ*, Xiao Y, Rasouli J, Wu WC, Ye SM, Guo XY, Zhu L, Rostami A, Wang LB, Zhang Y#,Li X#. Montelukast alleviates inflammation in experimental autoimmune encephalomyelitis by altering Th17 differentiation in a mouse model. Immunology. 2021;163(2):185-200. (SCIII区, IF=7.394);
26. Guo YX*, Zhang Y*, Gao Y, Deng SY, Wang LM, Li CQ#,Li X#.Role of Plant-derivednatural compounds inexperimental autoimmuneencephalomyelitis:a review of thetreatmentpotential and developmentstrategy. Frontiers in Pharmacology. 2021; 12:639651. (SCI II区, Top journal,IF=5.810);
27. Guo YX*, Wang N*, Wu WC, Li CQ, Chen RH, Zhang Y,Li X#,The Role of miR-23b in Cancer and Autoimmune Disease. Journal of Oncology. 2021; 2021 :6473038. (IF=4.375);
28. Zhang Y*,Li X*, Ciric B, Curtis M, Chen W, Rostami A#, Zhang G#.A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.Proceedings of the National Academy of Sciences, 2020; 117(16): 9082-9093. (SCI I区, IF =9.580, *co-first author)；
29. Wu W, Song S, Zhang Y,Li X#.Role of Extracellularvesicles in autoimmunepathogenesis.Frontiers in Immunology.2020; 11:579043. (SCI II区, Top journal, IF =7.562);
30. Tian J, Cassella G, Zhang Y, Rostami A,Li X#. Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases. International Journal of Biological Sciences. 2020;16(4):620-632.(SCI II区, IF= 4.858);
31. Yang T*,Li X*, Yu J, Deng X, Shen P, Jiang Y, Zhu L, Wang Z, Zhang Y.Eriodictyol suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis. Food& Function. 2020; 11(8):6875-6888. (SCI I区, Top journal, IF =4.171, *co-first author);
32. Tian J*,Li X*, Zhao L*, Shen P, Wang ZZ, Zhu L, Li CQ, Su C, Zhang Y. Glycyrrhizic Acid Promotes Neural Repair by Directly Driving Functional Remyelination. Food & Function. 2020; 11(1):992-1005. (SCI I区, Top journal, IF=4.171, *co-first author).
33. Zhang Y, Lu XY, Casella G, Tian J, Ye ZQ, Yang T, Han J, Jia L, Rostami A, Li X#. Generation of Oligodendrocyte Progenitor Cells from Mouse Bone Marrow Cells. Frontiers in Cellular Neuroscience. 2019; 13:247. (SCI II区, IF =4.300).
四、获奖情况
1. 《靶向中枢神经系统的药物递送载体平台的开发与应用》，2022年获得陕西省科技工作者创新创业大赛三等奖，第一完成人；
2. 《靶向CNS的细胞外囊泡对实验性自身免疫性脑脊髓炎的治疗效果研究》，2021获得国际神经再生论坛青年优秀报告奖-金奖。
3. 《干细胞外泌体的规模化提取技术研发》，2021年获得第六届中国创新挑战赛（西安）硬科技发展专题赛优秀奖，第一完成人；
4. 《靶向中枢神经系统精准药物递送系统的开发及应用》，2020年获得陕西省科技工作者创新创业大赛三等奖，第一完成人；
5.《靶向中枢神经系统细胞外囊泡可增强药物在多发性硬化症等疾病中促进髓鞘再生》，2023陕西省第七届究生创新成果展二等奖（指导教师）；
6.《靶向中枢神经系统的外泌体载药平台的开发与应用》，2023第八届全国大学生生命科学竞赛陕西赛区二等奖（指导教师）。
